What is Myasthenia Gravis?
This Myasthenia Gravis can be defined as a disease of chronic autoimmune condition, which affects skeletal muscles of the body. This disease also characterized by progressive degeneration of the voluntary muscles causing them to become weak and functionally useless.
It is hallmark of all the diseases, which means literally it grave muscle weakness, and weakness of some of the important muscles such as eyes, eyelids, face muscles involved in chewing, talking, swallowing, etc.
Factors Responsible for MG
So far all the researchers could confirm that faulty antibodies are responsible for the expression of MG. And apart from this main reason; some genetic predispositions are also well known to trigger the disease. There are some of the common environmental factors which are noted to worsen the symptoms are as below:
- Extreme Heat
- Some medications such as beta blockers, etc.
Some More Symptoms Associated With The MG
Overuse of the affected muscle, the pain and weakness of the muscle increases. So, it has been observed that symptoms generally improve with the rest, but tend to progress over the period of time. Some of the general symptoms may include:
- The limbs weakness
- Having Difficulty in chewing and swallowing
- Chronic fatigue
- No clear vision, drooping eyelid
- Breathing becomes difficult
- bowel movement is unusual
- Unstable gait
- Frequent change facial expressions
- Improper speech
How Stem Cells treatment this
Stem cells are like the mother cells which takeresponsibility in developing an entire human body from a tiny two celled embryo, because of their unlimited divisions and strong ability to differentiate into all the cells of different lineage. Thecapability and the power of stem cells have been harnessed by the technology to isolate them outside the human body and concentrate in the clean environment and implant back.
Hence these stem cells treatment involves administration of concentrated cells in the area to be treated.Whereasthey can colonize in the required area to be treated and adapt the properties of resident stem cells and initiate some of the lost functions that have been compromised by the disease or injury.In recent years, after so many years of research, it has been believed that it is better to alter the microenvironment with the application of stem cells instead of suppressing the immune system. Mesenchymal stem cells are known to have angiogenic, transdifferentiation and homing properties, which are useful for forming new blood vessels, differentiating into required targeted cells and creation of microenvironment for the faster secretion of immune cells. All over the world studies have confirmed considerable decrease in the antibodies against acetylcholine receptors after stem cells treatment on mice